Kane Lab

2024

• “Inhibition of Toll-Like Receptor 4 Using Small Molecule, TAK-242, Protects Islets from Innate Immune Responses”, Jordan Mattke, Carly M Darden, Srividya Vasu, Michael C Lawrence, Jeffrey Kirkland, Robert R Kane, Bashoo Naziruddin* Cells, 2024, 13(5), 416.
   

• “Toll-Like Receptor 4 in Pancreatic Damage and Immune Infiltration in Acute Pancreatitis”, Jordan Mattke, Carly M Darden, Michael C Lawrence, Jayachandra Kuncha, Yumna Ali Shah, Robert R Kane, and Bashoo Naziruddin Frontiers in Immunology, 2024, 15:1362727.
   

2023​

• “Endosomal trafficking inhibitor EGA can control TLR7-mediated IFNα, but not proinflammatory cytokine, expression by human plasmacytoid dendritic cells”, Matthew J Wiest, Laurie Baert, Chao Gu, Kevin M Gayler, Hyoungjun Ham, Laurent Gorvel, Mira T Keddis, Leroy W Griffing, Hyemee Joo, Jean-Pierre Gorvel, Daniel D Billadeau, Robert R. Kane, and Sangkon Oh  Frontiers in Immunology, 2023, 14.

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• “Sulfonamide prodrugs with a two-stage release mechanism for the efficient delivery of the TLR4 antagonist TAK-242”, Jessica H. Kostyo, Avery T. Lallande, Chloë A. Sells, Mina R. Shuda, and Robert R. Kane,ACS Medicinal Chemistry Letters, 2023, 14(1), 110–115.

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2022

• “Effect of Rubus ideaus L. consumption during pregnancy on maternal mice and their offspring”, Marie Hastings-Tolsma, Ryan T. Stoffel, Alexandra L Quintana, Robert R. Kane, Jacob Turner, Xuan Wang,
  J. Medicinal Food, 2022, (2), 183-191.

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2021​

• “Gemfibrozil derivatives as activators of soluble guanylyl cyclase – a structure- activity study”, Kevin M. Gayler, Jeremy M. Quintana, Jordan Mattke, Michael A. Plunk, Jessica H. Kostyo, Johann Karunananthan, Harold Nguyen, Mina Shuda, Liam Ferreira, Hannah Baker, Alexandra L. Quintana, Iraida Sharina, Robert R. Kane, Emil Martin, European Journal Medicinal Chemistry, 2021, 224, 113729.

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• "Dectin-1 controls TSLP-induced Th2 response by regulating STAT3, STAT6, and p50-RelB activities in dendritic cells”, Chao Gu, Katherine Upchurch, Joshua Horton, Ling Ni, Mathew Wiest, Sandra Zurawski, Robert Coffman, Mark Millard, Robert Kane, HyeMee Joo, Lisa Miller, SangKon Oh, Frontiers in Immunology, 2021, 12, 2612.

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• “Design and Catalyzed Activation of Mycophenolic Acid Prodrugs”, Michael A. Plunk, Jeremy M. Quintana, Carly M. Darden, Michael C. Lawrence, Bashoo Naziruddin, and Robert R. Kane, ACS Med Chem Lett 2021, 12(5), 812–816.

 

2020

• “Design and Catalyzed Activation of Tak-242 Prodrugs for Localized Inhibition of TLR4-Induced Inflammation”,Michael A. Plunk, Alyssa Alaniz, Olatunde P. Olademehin, Thomas L. Ellington, Kevin L. Shuford, Robert R. Kane, ACS Med Chem Lett 2020, 11(2), 141-146.
   

 

2018​

• “Chemical Strategies for Improving Islet Transplant Outcomes”, Jeremy M. Quintana, Alexandra L. Stinchcomb, Jessica H. Kostyo, Blair M. Robichaud, Michael A. Plunk, Robert R. Kane, OBM Transplantation 2018, 2(4), 036.

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• "Early TLR-4 blockade attenuates sterile inflammation-mediated stress in islets during isolation and promotes successful transplant outcomes in mice”, Charles A. Chang, Kayla Murphy, Robert R. Kane, Michael Lawrence, Bashoo Naziruddin Transplantation 2018, 102(9), 1505-1513.

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• “Ex-vivo generation of drug-eluting islets improves transplant outcomes by inhibiting TLR4-Mediated NFkB upregulation”, Charles A. Chang, Babatope Akinbobuyi, Jeremy M. Quintana, Gumpei Yoshimatsu, Bashoo Naziruddin, Robert R. Kane, Biomaterials 2018, 159C, 13-24.​

 

2016

• “Synthesis and immunostimulatory activity of substituted TLR7 agonists”, Babatope Akinbobuyi, Lei Wang, Katherine C. Upchurch, Matthew R. Byrd, Charles A. Chang, Jeremy M. Quintana, Rachel E. Petersen, Zacharie J. Seifert, José R. Boquin, SangKon Oh, and Robert R. Kane, Bioorganic and Medicinal Chemistry Letters 2016, 26, 4246-4249.​

 

2015

• “New TLR7 Agonists with Improved Humoral and Cellular Immune Responses”, Katherine C. Upchurch, José R. Boquín, Wenjie Yin, Yaming Xue, HyeMee Joo, Robert R. Kane, and SangKon Oh, Immunology Letters 2015, 168(1), 89-97.

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• “Facile syntheses of functionalized toll-like receptor 7 agonists”, Babatope Akinbobuyi, Matthew R. Byrd, Charles A. Chang, Mysa Nguyen, Zacharie J. Seifert, Anne-Laure Flamar, Gerard Zurawski, Katherine C. Upchurch, SangKon Oh, Stephen H. Dempsey, Thomas J. Enke, John Le, Hunter J. Winstead, José R. Boquín, and Robert R. Kane Tetrahedron Letters 2015, 56(2), 458-460.

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• “Comparison of surface modification chemistries in mouse, porcine, and human islets”, Jeffrey A. SoRelle, Mazhar A. Kanak, Takeshi Itoh, Joshua M. Horton, Bashoo Naziruddin, Robert R. Kane, J. Biomed. Mater. Res. Part A 2015, 103(3), 869-877.

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2008

• “History of the biomedical studies PhD program: a joint graduate program of the Baylor Health Care System and Baylor University”, Christine R. Morel, Joshua M. Horton, Han Peng, Kangling Xu, Sushil K. Batra, Jonathan P. Miles, and Robert R. Kane, Baylor University Medical Center Proceedings 2008, 21(4), 403-410.

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2007

• “Development of a photochemical method for meniscal repair:  A preliminary study”, Carolyn P. Skurla, Aruna Perera, Christopher T. Towe, Peter R. Robertson, Jennifer L. Healy, and Robert R. Kane, J. Biomechanics 2007, 40(13), 220-224. 

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2005

• “Synthesis and crystal structures of cis- and trans-1-(3'-N, N-dimethylthiocarbamoyl-4'-methoxy)-2(3", 4", 5"-trimethoxyphenyl) ethene”, Daniel A. Ramirez, Jianxing Zhang, Kevin Klausmeyer, and Robert R. Kane, J. Chem. Crystallography 2005, 35(3), 227-232.  

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• “Synthesis and in vitro Biological Evaluation of Aminal and Thioaminal Analogues of Cordycepin”, Hui-Min Chang, Jesse Oakes, Anders Olsson, Luminita Panaitescu, B. Mark Britt, Christopher M. Kearney, and Robert R. Kane, Letters in Drug Design & Discovery 2005, 2(2),133-136. 

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2004

• “Suture-Less Avascular Meniscal Repair: A Preliminary Animal Study”, Fabian E. Pollo, Robert W. Jackson, Robert R. Kane, Hui-Min Chang, Jianxing Zhang, Chad P. Dieterichs, and Stephan Riedel, Arthroscopy: The Journal of Arthroscopic and Related Surgery 2004, 20(8), 824-830. 

 

• “Photochemical Tissue Bonding Using 4-Amino-1,8-Naphthalimides”, Jianxing Zhang, R. Jeremy Woods, Phillip B. Brown, Richard A. Mowery, Fabian Pollo, Robert W. Jackson, and Robert R. Kane, Journal of Biomedical Optics 2004, 9(5), 1089-1092. 

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• “Combretastatin Family Member OXI4503 induces Tumor Vascular Collapse Through the Induction of Endothelial Apoptosis”, Yezhou Sheng, Jianyi Hua, Kevin G. Pinney, Charles M. Garner, Robert R. Kane, Joseph A. Prezioso, David J. Chaplin, and Klaus Edvardsen, International Journal of Cancer 2004, 111, 604-610. 

2003

• “Protein Crosslinking by 1,8-Naphthalimides: Influence of the 4-Substituent”, R. Jeremy Woods, Jianxing Zhang, Charalene R. Green, and Robert R. Kane, ARKIVOC 2003, (xiii), 109-118. 

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• “OXI4503 A Novel Vascular Targeting Agent: Effects on Bloodflow and Antitumor Activity in Comparison to Combretastatin A-4 Phosphate”, Jianyi Hua, Yezhou Sheng, Kevin Pinney, Charles M. Garner, Robert R. Kane, Joseph A. Prezioso, George R. Pettit, David J. Chaplin, and Klaus Edvardsen, Anticancer Research 2003, 23, 1433-1440. 

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• “[(E)-1-(2-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-ethene]”, Jianxing Zhang, ShouFeng Chen, Kevin K. Klausmeyer and Robert R. Kane, Acta Crys. C. 2003, C59, o381-o382.  

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• “Synthesis, in vitro, and in vivo Evaluation of Phosphate Ester Derivatives of Combretastatin A-4”, M. Devan Jonklaas, Jianxing Zhang, Klaus Edvardsen, Robert R. Kane, and Kevin. G. Pinney, Biochem. Med. Chem. Lett., 2003, 13(9), 1505-1508.

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• “Synthesis of deuterium-labeled 3-O-methyldopa and 4-O-methyldopa”, Aruna Perera, Hoa K. Nguyen, Keith Hyland, and Robert R. Kane, J. Labeled Cmpds. Radiopharm. 2003, 46(5), 389-394. 

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2002

• “Synthesis and Photochemical Protein Crosslinking Studies of Hydrophilic Naphthalimides”, Jianxing Zhang, R. Jeremy Woods, Philip B. Brown, Kap Duk Lee, and Robert R. Kane, Biochem. Med. Chem. Lett. 2002, 12(6), 853-856. 

2001

• “Reductive Alkylation of Aromatic Amines via Amidine Intermediates”, Jianxing Zhang, Hui-Min Chang, and Robert R. Kane, Synlett 2001, (5), 643-645.  

2000

• “The Synthesis of 3’- and 5’-Iminodiacetic Acid Derivatives of Thymidine and Their Incorporation into Synthetic Oligonucleotides”, M. Devan Jonklaas and Robert R. Kane, Tetrahedron Letters 2000, 41, 4035-3037.  

1999

• “Pharmacokinetics and Central Nervous System Toxicity of Declopramide (3-Chloroprocainamide) in Rats and Mice”, Jianyi Hua, Robert R. Kane, and Ronald W. Pero, Anticancer Drugs 1999, 10, 7988. 

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• “Comparison of Antitumor Activity of Declopramide (3-Chloroprocainamide) and N-AcetylDeclopramide”, Jianyi Hua, Carl Bryngelsson, Robert R. Kane, and Ronald W. Pero, Anticancer Research 1999, 19(1A), 285-290.  

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• “Toward a Cancer Therapy with Boron-Rich Oligomeric Phosphate Diesters Which Target the Cell Nucleus”, Akira Nakanishi, Lufeng Guan, Robert R. Kane, Harumi Kasamatsu, and M. Frederick Hawthorne, Proceedings of the National Academy of Sciences (USA) 1999, 96(1), 238-241.  

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1998

• “Efficient Asymmetric Synthesis of the C9-C21 Portion of the Aplysiatoxin and Oscillatoxin Marine Natural Products”, Robert D. Walkup, Jeffrey D. Kahl, and Robert R. Kane, Journal of Organic Chemistry 1998, 63(24), 9113-9116. 

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• “Homogeneous Immunoconjugates for Boron Neutron Capture Therapy: Design, Synthesis, and Preliminary Characterization”, Lufeng Guan, Letitia A. Wims, Robert R. Kane, Mark B. Smuckler, Sherie L. Morrison, and M. Frederick Hawthorne, Proceedings of the National Academy of Sciences (USA) 1998, 95(22), 13206-13210.

1997

• “The Synthesis, Purification, Characterization, And Derivatization Of Boron-Rich Oligophosphates”, Robert R. Kane, Young Soo Kim, and M. Frederick Hawthorne, Advances in Neutron Capture Therapy, 1997. Edited by B. Larson, J. Crawford, and R. Weinreich, eds., Elsevier Science; Amsterdam, pp 126-130.

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• “Approaches To The Selective Concentration Of Boron-Rich Oligophosphates In Tumors”, Robert R. Kane, Lufeng Guan, Kenneth Shelly, and M. Frederick Hawthorne, Advances in Neutron Capture Therapy, 1997. Edited by B. Larson, J. Crawford, and R. Weinreich, eds., Elsevier Science; Amsterdam, pp 362-365. 

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• "Rods, Rings, Balls, and Strings!", Mark D. Mortimer, Wei Jiang, Zhiping Zheng, Robert R. Kane, Igor T. Chizhevsky, Carolyn B. Knobler, and M. Frederick Hawthorne, in Modular Chemistry, J. Michl, Ed., Kluwer Academic Publishers, Dordrecht (the Netherlands), 1997, 551–564. 

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1996

• "Boron-Rich Oligophosphates – Novel Molecules for Use in BNCT", Robert R. Kane, Karin Drechsel, Young-Soo Kim, Cynthia L. Beno, Christine S. Lee, Gabriel Mendez, Solomon Romano, and M. Frederick Hawthorne, Neutron Capture Therapy of Human Cancers, 1996, Y. Mishima, Ed., Plenum Press, New York, in press. 

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• "The Novel [n-B20H18]2- Induced Nucleophilic Ring-Opening of Tetrahydrofuran by Alkoxide Anions", Fangbiao Li, Kenneth Shelly, Robert R. Kane, Carolyn B. Knobler, and M. Frederick Hawthorne, Angewandte Chemie Int. Ed. Engl. 1996, 35(22), 2646-2649. 

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• "Targeting of Anionic nido-Carboranes to Human Colon Carcinoma Cells with Bispecific Antibodies", F. James Primus, Roger H. Pak, Karen J. Rickard-Dickson, Robert R. Kane, and M. Frederick Hawthorne, Bioconjugate Chemistry 1996, 7(5), 532–535. 

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• "Synthesis and Structure of the Polyhedral [µ-B20H17OH]2- Borane Anion Containing Both Oxygen- and Hydrogen-Bridge Bonds", Fangbiao Li, Kenneth Shelly, Robert R. Kane, Carolyn B. Knobler, and M. Frederick Hawthorne, Journal of the American Chemical Society 1996, 118(27), 6506–6507.

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1995

• "Preparation and Properties of nido-Carborane-specific Monoclonal Antibodies for Potential Use in Boron Neutron Capture Therapy (BNCT) of Cancer", Roger H. Pak, F. James Primus, Karen J. Rickard-Dickson, Lai Ling Ng, Robert R. Kane, and M. Frederick Hawthorne, Proceedings of the National Academy of Sciences (USA) 1995, 92, 6986-6990. 

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• "Synthesis of New Building Blocks for Boron-Rich Oligomers in Boron Neutron Capture Therapy (BNCT). II.  Monomers Derived From 2,2-Disubstituted-1,3-Diols", Young Soo Kim, Robert R. Kane, Cynthia L. Beno, Solomon Romano, Gabriel Mendez, and M. Frederick Hawthorne, Tetrahedron Letters 1995, 36(29), 5147-5150. 

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1994

• "Synthesis and Characterization of Oligomeric nido-Carboranyl Phosphate Diester Conjugates to Antibodies and Antibody Fragments for Potential Use in Boron Neutron Capture Therapy of Solid Tumors", Christine J. Chen, Robert R. Kane, F. James Primus, Gyorgy Szalai, M. Frederick Hawthorne, and John E. Shively, Bioconjugate Chemistry 1994, 5(6), 557-564.

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• "Synthesis and Structural Characterization of [(CH3)3NH][nido-9,11-I2-7,8-C2B9H10] and [(CH3)3NH][nido-9-I-7,8-C2B9H11]", Roger H. Pak, Robert R. Kane, Carolyn B. Knobler, and M. Frederick Hawthorne, Inorganic Chemistry 1994, 33(23), 5355-5357. 

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• "Synthesis of New Building Blocks for Boron-Rich Oligomers in Boron Neutron Capture Therapy (BNCT). I.", Karin Drechsel, Christine S. Lee, Eamon W. Leung, Robert R. Kane, and M. Frederick Hawthorne, Tetrahedron Letters 1994, 35(34), 6217-6220. 

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1993

• "Automated Syntheses of Carborane-Derived Homogeneous Oligophosphates", Robert R. Kane, Karin Drechsel, and M. Frederick Hawthorne, J. Am. Chem. Soc. 1993, 115(19), 8853-8854. 

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• "Solution-Phase Synthesis of Boron-Rich Oligophosphates", Robert R. Kane, Christine S. Lee, Karin Drechsel, and M. Frederick Hawthorne, Journal of Organic Chemistry 1993, 58(12), 3227-3228. 

• "Solution-Phase Segment Synthesis of Boron-Rich Peptides", Robert R. Kane, Roger H. Pak, and M. Frederick Hawthorne, Journal of Organic Chemistry 1993, 58(5), 991-992. 

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• "Novel Carboranyl Diols and Their Derived Phosphate Esters", Robert R. Kane, Christine S. Lee, Cynthia L. Coe, Melissa A. St. Rose, Karin Drechsel, and M. Frederick Hawthorne, in Advances in Neutron Capture Therapy, A.H. Soloway, Ed., Plenum Press, New York, 1993, 293-296. 

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• "Novel Carboranyl Amino Acids and Peptides", Robert R. Kane, Roger H. Pak, Lai-Ling Ng, and M. Frederick Hawthorne, in Advances in Neutron Capture Therapy, A.H. Soloway, Ed., Plenum Press, New York, 1993, 273-276. 

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1991

• "A Stereoselective Route to the Spirobicyclic Ring System of Oscillatoxin D", Robert D. Walkup, P. Douglas Boatman, Jr., Robert R. Kane, and Raymond T. Cunningham, Tetrahedron Letters 1991, 32(32), 3937-3940. 

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1990

• "Expeditious Synthesis of a Key C9-C21 Subunit of the Aplysiatoxins and Oscillatoxins", Robert D. Walkup, Robert R. Kane, P. Douglas Boatman, Jr., and Raymond T. Cunningham, Tetrahedron Letters  1990, 31(52), 7587-7590. 

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• "Effects of Substituents Upon a Radical Cyclization of B-Chloroethylsilyl Enol Ethers", Robert D. Walkup, Robert R. Kane, and Nihal U. Obeyesekere, Chemistry Letters 1990, (7), 1055-1058.

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• "An a-Alkylation/Reduction of Ketones via Radical Cyclizations of b-Chloroethylsilyl Enol Ethers", Robert D. Walkup, Robert R. Kane, and Nihal U. Obeyesekere, Tetrahedron Letters  1990, 31(11), 1531-1534. 

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